The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

E Buzzetti, M Pinzani, EA Tsochatzis - Metabolism, 2016 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

H Tilg, TE Adolph, M Dudek, P Knolle - Nature metabolism, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

N Stefan, HU Häring, K Cusi - The lancet Diabetes & endocrinology, 2019 - thelancet.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. In
some patients with NAFLD, isolated steatosis can progress to advanced stages with non …

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

QM Anstee, G Targher, CP Day - Nature reviews Gastroenterology & …, 2013 - nature.com
NAFLD is a spectrum of progressive liver disease that encompasses simple steatosis,
NASH, fibrosis and, ultimately, cirrhosis. NAFLD is recognized as the hepatic component of …

Pathophysiology-based subphenoty** of individuals at elevated risk for type 2 diabetes

R Wagner, M Heni, AG Tabak, J Machann, F Schick… - Nature medicine, 2021 - nature.com
The state of intermediate hyperglycemia is indicative of elevated risk of develo** type 2
diabetes. However, the current definition of prediabetes neither reflects subphenotypes of …

Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease

G Targher, CP Day, E Bonora - New England Journal of Medicine, 2010 - Mass Medical Soc
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial

AY Meir, E Rinott, G Tsaban, H Zelicha, A Kaplan… - Gut, 2021 - gut.bmj.com
Objective To examine the effectiveness of green-Mediterranean (MED) diet, further restricted
in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic …

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

AL Birkenfeld, GI Shulman - Hepatology, 2014 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are
all strongly associated and are all reaching epidemic proportions. Whether there is a causal …

Adiposity and cancer risk: new mechanistic insights from epidemiology

AG Renehan, M Zwahlen, M Egger - Nature Reviews Cancer, 2015 - nature.com
Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for
many common adult cancers. Over the past decade, epidemiological data have shown that …