Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …

Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

Thyroid cancers are the most common endocrine malignancy and approximately 2% of
thyroid cancers are anaplastic thyroid carcinoma (ATC), one of the most lethal and treatment …

The constitutive activation of Janus Kinase/Signal Transducer and Activator of Transcription
(JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related …

The Metastatic progression of solid tumors, such as thyroid cancer is a complex process
which involves various factors. Current understanding on the role of epithelial …

Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …

The tumor microenvironment (TME) harbors a hidden universe of interactions that
profoundly shape the behavior of head and neck cancers (HNCs). HNCs are not merely …

Background Recent studies have indicated that deubiquitinating enzymes (DUBs) are
related to the stem-cell pathway network and chemo-resistance in cancer. Ubiquitin-specific …

Ovarian cancer (OC) is one of the most lethal gynecologic malignancies. Due to the lack of
specific symptoms and screening methods, this disease is usually diagnosed only at an …

Anaplastic thyroid carcinoma (ATC) is a deadly disease with a poor prognosis. Thus, there is
a pressing need to determine the mechanism of ATC progression. The homeobox D9 …