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A stochastic vs deterministic perspective on the timing of cellular events
Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …
in cell state are driven by molecular processes; of these many are initiated when molecule …
Exact distribution of threshold crossing times for protein concentrations: Implication for biological timekee**
Stochastic protein accumulation up to some concentration threshold sets the timing of many
cellular physiological processes. Here we obtain the exact distribution of first threshold …
cellular physiological processes. Here we obtain the exact distribution of first threshold …
Controlling gene expression timing through gene regulatory architecture
Gene networks typically involve the regulatory control of multiple genes with related function.
This connectivity enables correlated control of the levels and timing of gene expression …
This connectivity enables correlated control of the levels and timing of gene expression …
First passage time in post-transcriptional regulation by multiple small RNAs
The post-transcriptional regulation of a protein by multiple small RNA molecules has been
formulated as a stochastic process. An approximate solution of the master equation shows …
formulated as a stochastic process. An approximate solution of the master equation shows …
First passage time properties of miRNA-mediated protein translation
An important function of microRNAs in gene regulation is to repress the protein synthesis in
a multi-step process with implications in timing efficiency of the regulatory network. We …
a multi-step process with implications in timing efficiency of the regulatory network. We …
Timing effciency in small-rna-regulated post-transcriptional processes
Gene regulation in a cellular environment is a stochastic phenomenon leading to a large
variability in mRNAs and protein numbers that are often produced in bursts. The regulation …
variability in mRNAs and protein numbers that are often produced in bursts. The regulation …
Feedback strategies for threshold crossing of protein levels at a prescribed time
The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …
Effect of gene-expression bursts on stochastic timing of cellular events
Gene expression is inherently a noisy process which manifests as cell-to-cell variability in
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …
Spatial moment description of birth–death–movement processes incorporating the effects of crowding and obstacles
Birth–death–movement processes, modulated by interactions between individuals, are
fundamental to many cell biology processes. A key feature of the movement of cells within in …
fundamental to many cell biology processes. A key feature of the movement of cells within in …
First-passage time statistics of stochastic transcription process for time-dependent reaction rates
Transcription in gene expression is an intrinsically noisy process which involves production
and degradation of mRNAs. An important quantity to describe this stochastic process is the …
and degradation of mRNAs. An important quantity to describe this stochastic process is the …