Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

The tumor immune microenvironment plays a vital role in the metastasis of colorectal cancer.
As one of the most important immune cells, macrophages act as phagocytes, patrol the …

Colorectal cancer is a common malignant tumor, whose growth and metastasis are
influenced by numerous factors. MicroRNAs have garnered increasing attention in recent …

Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly
understood pathogenesis. We performed single-cell transcriptomic profiling of 28,695 …

Simple Summary Cutaneous Melanoma (CM), arising from pigment-producing melanocytes
in the skin, is an aggressive cancer with high metastatic potential. While cutaneous …

Blockade of vascular endothelial growth factor (VEGF) signaling with bevacizumab, a
humanized anti-VEGF monoclonal antibody (mAb), or with receptor tyrosine kinase …

The L1000 technology, a cost-effective high-throughput transcriptomics technology, has
been applied to profile a collection of human cell lines for their gene expression response …

Advances in cancer immunotherapy are improving treatment successes in many distinct
cancer types. Nonetheless, most tumors fail to respond. Age is the biggest risk for most …

The lymphatic kidney system plays a crucial role in managing interstitial fluid removal,
regulating fluid balance, and tuning immune response. It also assists in the reabsorption of …