Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Y Geng, Z Wang, J Zhou, M Zhu, J Liu… - Chemical Society …, 2023 - pubs.rsc.org
Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …

Stimuli-responsive ferroptosis for cancer therapy

N Kang, S Son, S Min, H Hong, C Kim, J An… - Chemical Society …, 2023 - pubs.rsc.org
Ferroptosis, an iron-dependent programmed cell death mechanism, is regulated by distinct
molecular pathways of lipid peroxidation caused by intracellular iron supplementation and …

An Activity‐Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO) in the Alzheimer's Disease Brain

P Wang, L Yu, J Gong, J **ong, S Zi, H **e… - Angewandte …, 2022 - Wiley Online Library
Peroxynitrite (ONOO−) plays a critical role in Alzheimer's disease (AD). To reveal the
ONOO− influx in AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was …

Fluorescent diagnostic probes in neurodegenerative diseases

J Zhou, P Jangili, S Son, MS Ji, M Won… - Advanced …, 2020 - Wiley Online Library
Neurodegenerative diseases are debilitating disorders that feature progressive and
selective loss of function or structure of anatomically or physiologically associated neuronal …

Pharmacological role of functionalized gold nanoparticles in disease applications

WC Ko, SJ Wang, CY Hsiao, CT Hung, YJ Hsu… - Molecules, 2022 - mdpi.com
Gold has always been regarded as a symbol of nobility, and its shiny golden appearance
has always attracted the attention of many people. Gold has good ductility, molecular …

Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice

SS Hou, J Yang, JH Lee, Y Kwon… - Nature biomedical …, 2023 - nature.com
Non-invasive methods for the in vivo detection of hallmarks of Alzheimer's disease can
facilitate the study of the progression of the disease in mouse models and may enable its …

In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission

S Wang, L Liu, Y Fan, AM El-Toni, MS Alhoshan… - Nano Letters, 2019 - ACS Publications
Quantitatively imaging the spatiotemporal distribution of biological events in living
organisms is essential to understand fundamental biological processes. Self-calibrating …

Simultaneous Sensing of H2S and ATP with a Two-Photon Fluorescent Probe in Alzheimer's Disease: toward Understanding Why H2S Regulates Glutamate …

P Sun, HC Chen, S Lu, J Hai, W Guo, YH **g… - Analytical …, 2022 - ACS Publications
Energy deprivation and reduced levels of hydrogen sulfide (H2S) in the brain is closely
associated with Alzheimer's disease (AD). However, there is currently no fluorescent probe …

A general approach to convert hemicyanine dyes into highly optimized photoacoustic scaffolds for analyte sensing

SH Gardner, CJ Brady, C Keeton… - Angewandte Chemie …, 2021 - Wiley Online Library
Most photoacoustic (PA) imaging agents are based on the repurposing of existing
fluorescent dye platforms that exhibit non‐optimal properties for PA applications. Herein, we …

Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and tau aggregates in Alzheimer's disease

H Rai, S Gupta, S Kumar, J Yang… - Journal of Medicinal …, 2022 - ACS Publications
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …