Process analytical technique (PAT) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing
The transition to continuous biomanufacturing is considered the next step to reduce costs
and improve process robustness in the biopharmaceutical industry, while also improving …
and improve process robustness in the biopharmaceutical industry, while also improving …
Field-flow fractionation: New and exciting perspectives in polymer analysis
The development of advanced polymeric materials requires state-of-the-art synthesis and
molecular characterization protocols. Only the precise knowledge of molecular structure …
molecular characterization protocols. Only the precise knowledge of molecular structure …
Role of carbonyl modifications on aging-associated protein aggregation
Protein aggregation is a common biological phenomenon, observed in different
physiological and pathological conditions. Decreased protein solubility and a tendency to …
physiological and pathological conditions. Decreased protein solubility and a tendency to …
The dual nature of biomimetic melanin
Melanin-inspired nanomaterials offer unique photophysical, electronic and radical
scavenging properties that are widely explored for health and environmental preservation …
scavenging properties that are widely explored for health and environmental preservation …
Tracking heme-protein interactions in healthy and pathological human serum in native conditions by miniaturized FFF-multidetection
The interaction of heme with blood serum proteins plays an important role in many
physiological and pathological processes involving enzyme activity, gene expression and …
physiological and pathological processes involving enzyme activity, gene expression and …
Field-flow fractionation: A gentle separation and characterization technique in biomedicine
X Zhang, Y Li, S Shen, S Lee, H Dou - TrAC Trends in Analytical Chemistry, 2018 - Elsevier
Abstract Field-flow fractionation (FFF), a gentle tool for separation and characterization of
macromolecules and particles, has attracted increasing interest in recent years due to its …
macromolecules and particles, has attracted increasing interest in recent years due to its …
Field-flow fractionation in molecular biology and biotechnology
Field-flow fractionation (FFF) is a family of single-phase separative techniques exploited to
gently separate and characterize nano-and microsystems in suspension. These techniques …
gently separate and characterize nano-and microsystems in suspension. These techniques …
An ultracentrifugation–hollow-fiber flow field-flow fractionation orthogonal approach for the purification and map** of extracellular vesicle subtypes
In the course of their life span, cells release a multitude of different vesicles in the
extracellular matrix (EVs), constitutively and/or upon stimulation, carrying signals either …
extracellular matrix (EVs), constitutively and/or upon stimulation, carrying signals either …
Characterization of red wine native colloids by asymmetrical flow field-flow fractionation with online multidetection
Colloids are an important component of wines, but their study is challenging due to their
instability. Asymmetrical Flow-Field Flow Fractionation (AF4)-multidetection is here …
instability. Asymmetrical Flow-Field Flow Fractionation (AF4)-multidetection is here …
Application of af4-multidetection to liraglutide in its formulation: Preserving and representing native aggregation
Aggregation is among the most critical parameters affecting the pharmacological and safety
profile of peptide Active Pharmaceutical Ingredients (APIs). For this reason, it is of utmost …
profile of peptide Active Pharmaceutical Ingredients (APIs). For this reason, it is of utmost …