Structural determinants of stimuli-responsiveness in amphiphilic macromolecular nano-assemblies

H Liu, HH Lu, Y Alp, R Wu, S Thayumanavan - Progress in Polymer …, 2024 - Elsevier
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo
controlled structural transformations and generate diverse macroscopic phenomenon under …

Control of metalloenzyme activity using photopharmacophores

NN Mafy, DB Hudson, EL Que - Coordination chemistry reviews, 2024 - Elsevier
Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …

Influence of Polymer Structure and Architecture on Drug Loading and Redox-Triggered Release

P Wu, J Gao, P Prasad, K Dutta, P Kanjilal… - …, 2021 - ACS Publications
Disulfide cross-linked nanoassemblies have attracted considerable attention as a drug
delivery vehicle due to their responsiveness to the natural redox gradient in biology …

Cellular AND gates: Synergistic recognition to boost selective uptake of polymeric nanoassemblies

J Gao, P Wu, A Fernandez, J Zhuang… - Angewandte …, 2020 - Wiley Online Library
The development of nanoparticle‐based biomedical applications has been hampered due
to undesired off‐target effects. Herein, we outline a cellular AND gate to enhance uptake …

Tracking Microenvironmental Response on Self‐Assembled Phthalocyanine Systems–Adaptive and Non‐Adaptive Antibacterial Photosensitization

A Galstyan - Chemistry–A European Journal, 2024 - Wiley Online Library
Self‐assembly has proven to be one of the effective methods for the formation of nanoscale
therapeutics without the need to use nanodelivery systems. Such minimal models of …

A New Strategy for Reporting Specific Protein Binding Events at Aqueous–Liquid Crystal Interfaces in the Presence of Non-Specific Proteins

CS Park, K Iwabata, U Sridhar, M Tsuei… - … applied materials & …, 2019 - ACS Publications
Aqueous–liquid crystal (LC) interfaces offer promise as responsive interfaces at which
biomolecular recognition events can be amplified into macroscopic signals. However, the …

Direct observation of liquid crystal droplet configurational transitions using optical tweezers

J Shechter, N Atzin, A Mozaffari, R Zhang, Y Zhou… - Langmuir, 2020 - ACS Publications
Liquid crystals (LCs) are easily influenced by external interactions, particularly at interfaces.
When rod-like LC molecules are confined to spherical droplets, they experience a …

Programmed Degradation of Hydrogels with a Double‐Locked Domain

J Lai, L Abune, N Zhao, Y Wang - … Chemie International Edition, 2019 - Wiley Online Library
The ability to control the degradation of a material is critical to various applications. The
purpose of this study was to demonstrate a concept of controlling degradation by using a …

Tunable enzyme responses in amphiphilic nanoassemblies through alterations in the unimer–aggregate equilibrium

J Gao, H Wang, J Zhuang, S Thayumanavan - Chemical Science, 2019 - pubs.rsc.org
Develo** design rules that offer tailorability in materials' response to enzymes is of great
importance, as such materials are of interest in a variety of biomedical applications including …

Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for Staphylococcus aureus

TM Koyasseril-Yehiya, A García-Heredia, F Anson… - Nanoscale, 2020 - pubs.rsc.org
The propensity of broad-spectrum antibiotics to indiscriminately kill both pathogenic and
beneficial bacteria has a profound impact on the spread of resistance across multiple …