The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

Mycobacterium tuberculosis strains of the Bei**g lineage are globally distributed and are
associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia …

Human cytomegalovirus (HCMV), a ubiquitous herpesvirus, causes a lifelong subclinical
infection in healthy adults but leads to significant morbidity and mortality in neonates and …

Successful treatment of human tuberculosis requires 6–9 months' therapy with multiple
antibiotics. Incomplete clearance of tubercle bacilli frequently results in disease relapse …

Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …

Background A significant body of evidence accumulated over the last century suggests a link
between hypoxic microenvironments within the infected host and the latent phase of …

Human tuberculosis is a complex disease caused by bacterial populations that are located
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …

Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …

A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …