Vascular calcification is a pathological process characterized by ectopic calcification of the
vascular wall. Medial calcifications are most often associated with kidney disease, diabetes …

Cardiovascular diseases (CVDs) are the foremost cause of mortality worldwide.
Atherosclerosis is the underlying pathology behind CVDs. Atherosclerosis is manifested …

Background Neferine exhibits therapeutic effects on anti-hypertension. However, the effect
of neferine on hypertensive vascular remodeling remains unexplored. Therefore, the current …

The discoidin domain receptor tyrosine kinases DDR1 and DDR2 are distinguished from
other kinase enzymes by their extracellular domains, which interact with collagen rather than …

Aging is a major risk factor for quintessential cardiovascular diseases, which are closely
related to arterial proinflammation. The age‐related alterations of the amount, distribution …

Molecular mechanisms underlying the diverse therapeutic effects of anti-diabetic metformin,
beyond its anti-hyperglycaemic effects, remain largely unclear. Metformin is reported to …

Age-related obesity significantly increases the risk of chronic diseases such as type 2
diabetes, cardiovascular diseases, hypertension, and certain cancers. The insulin–leptin …

Cardiovascular calcification is a pathological process commonly observed in the elderly.
Based on the location of the calcification, cardiovascular calcification can be classified into …

Relative resistance to apoptosis and the ability to proliferate and produce a collagen-rich
scar determine the critical role of cardiac fibroblasts in wound healing and tissue remodeling …

Cardiovascular diseases are a leading cause of morbidity and mortality world-wide. While
many factors like smoking, hypertension, diabetes, dyslipidaemia, a sedentary lifestyle, and …