A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Microorganisms have provided abundant sources of natural products which have been
developed as commercial products for human medicine, animal health, and plant crop …

An efficient genome-scale editing tool is required for construction of industrially useful
microbes. We describe a targeted, continual multigene editing strategy that was applied to …

Direct synthesis of ketones from aldehydes features high atom-and step-economy. Yet, the
coupling of aldehydes with unactivated alkyl C (sp3)-H remains challenging. Herein, we …

Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …

The carbene and photocatalyst co-catalyzed radical coupling of acyl electrophile and a
radical precursor is emerging as attractive method for ketone synthesis. However, previous …

A mechanism that enables direct aldehyde C–H functionalization has been achieved via the
synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild …

Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the
increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of …

3 Role of natural products in treatment of diseases 4 Antiinfective agents (including
antimalarials) 4.1 Antibacterials: b-lactams 4.2 Antibacterials: aminoglycosides 4.3 …