The landscape of cancer research and cancer care in China

Z Lu, Y Chen, D Liu, X Jiao, C Liu, Y Wang, Z Zhang… - Nature Medicine, 2023 - nature.com
The rising cancer incidence rate in China poses a substantial public health concern,
although there have been remarkable improvements in the country's cancer mortality and …

Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology

Z Wang, Y Liu, X Niu - Seminars in Cancer Biology, 2023 - Elsevier
Gastric cancer is a leading contributor to cancer incidence and mortality globally. Recently,
artificial intelligence approaches, particularly machine learning and deep learning, are …

Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial

YL Verschoor, J van de Haar, JG van den Berg… - Nature medicine, 2024 - nature.com
Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite
recent advancements, most patients die of their disease. Although immune checkpoint …

Multiplex immunofluorescence and single‐cell transcriptomic profiling reveal the spatial cell interaction networks in the non‐small cell lung cancer microenvironment

H Peng, X Wu, S Liu, M He, C **e… - Clinical and …, 2023 - Wiley Online Library
Background Conventional immunohistochemistry technologies were limited by the inability
to simultaneously detect multiple markers and the lack of identifying spatial relationships …

Neutrophil profiling illuminates anti-tumor antigen-presenting potency

Y Wu, J Ma, X Yang, F Nan, T Zhang, S Ji, D Rao… - Cell, 2024 - cell.com
Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing
functions across cancer types. However, given their short half-life, it remains challenging to …

Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multi-modal data

Z Chen, Y Chen, Y Sun, L Tang, L Zhang… - … and Targeted Therapy, 2024 - nature.com
The sole use of single modality data often fails to capture the complex heterogeneity among
patients, including the variability in resistance to anti-HER2 therapy and outcomes of …

[HTML][HTML] Artificial intelligence for predictive biomarker discovery in immuno-oncology: a systematic review

A Prelaj, V Miskovic, M Zanitti, F Trovo, C Genova… - Annals of …, 2023 - Elsevier
Background The widespread use of Immune checkpoint-inhibitors (ICI) has revolutionised
treatment of multiple cancer types. However, selecting patients who may benefit from ICI …

CLDN18. 2 expression and its impact on prognosis and the immune microenvironment in gastric cancer

C Wang, Y Wang, J Chen, Y Wang, C Pang… - BMC …, 2023 - Springer
Background The investigational use of zolbetuximab (IMAB362), a groundbreaking
monoclonal antibody medication targeting claudin 18.2 (CLDN18. 2), for treatment of …

Multiplex protein imaging in tumour biology

N de Souza, S Zhao, B Bodenmiller - Nature Reviews Cancer, 2024 - nature.com
Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Predictive biomarkers for immunotherapy in gastric cancer: current status and emerging prospects

W Hou, Y Zhao, H Zhu - International Journal of Molecular Sciences, 2023 - mdpi.com
Gastric cancer presents substantial management challenges, and the advent of
immunotherapy has ignited renewed hope among patients. Nevertheless, a significant …