[HTML][HTML] Aging, cancer, and inflammation: the telomerase connection
V Boccardi, L Marano - International Journal of Molecular Sciences, 2024 - mdpi.com
Understanding the complex dynamics of telomere biology is important in the strong link
between aging and cancer. Telomeres, the protective caps at the end of chromosomes, are …
between aging and cancer. Telomeres, the protective caps at the end of chromosomes, are …
TERT Promoter Alterations in Glioblastoma: A Systematic Review
N Olympios, V Gilard, F Marguet, F Clatot, F Di Fiore… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma is the most common malignant primary brain tumor in adults.
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation
T He, Z Hao, M Lin, Z **n, Y Chen, W Ouyang… - …, 2022 - Taylor & Francis
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential
for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying …
for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying …
Telomerase: a prominent oncological target for development of chemotherapeutic agents
Telomerase is a ribonucleoprotein (RNP) responsible for the maintenance of chromosomal
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …
[HTML][HTML] Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species
S Ju, MK Singh, S Han, J Ranbhise… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer is a multifaceted disease influenced by various mechanisms, including the
generation of reactive oxygen species (ROS), which have a paradoxical role in both …
generation of reactive oxygen species (ROS), which have a paradoxical role in both …
Tumor biomarkers for diagnosis, prognosis and targeted therapy
Y Zhou, L Tao, J Qiu, J Xu, X Yang, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …
tumors during tumorigenesis and progression, have been demonstrated to possess critical …
Biological and clinical perspectives of TERT promoter mutation detection on bladder cancer diagnosis and management
The telomerase reverse transcriptase (TERT) promoter mutations are associated with
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
The role of telomerase in breast Cancer's response to Therapy
E Judasz, N Lisiak, P Kopczyński, M Taube… - International journal of …, 2022 - mdpi.com
Currently, breast cancer appears to be the most widespread cancer in the world and the
most common cause of cancer deaths. This specific type of cancer affects women in both …
most common cause of cancer deaths. This specific type of cancer affects women in both …
NF-kB activation in canine cancer
Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical
and molecular features with a wide variety of human cancers, making this companion animal …
and molecular features with a wide variety of human cancers, making this companion animal …