Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as
ligand-activated transcription factors. They exist in three isoforms: PPARα, PPARβ/δ, and …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …

Polyunsaturated fatty acids (PUFAs) and their metabolites have a variety of physiological
roles including: energy provision, membrane structure, cell signaling and regulation of gene …

A reciprocal regulation exists between the central nervous and immune systems through
which the CNS signals the immune system via hormonal and neuronal pathways and the …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …