Liver disease accounts for two million deaths annually and is responsible for 4% of all
deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related …

Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due
to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular …

Acute-on-chronic liver failure (ACLF), which was described relatively recently (2013), is a
severe form of acutely decompensated cirrhosis characterised by the existence of organ …

Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …

The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …

The clinical course of cirrhosis is mostly determined by the progressive increase of portal
hypertension, hyperdynamic circulation, bacterial translocation and activation of systemic …

Acute-on-chronic liver failure (ACLF) is a syndrome characterised by acute decompensation
of chronic liver disease associated with organ failures and high short-term mortality. Alcohol …

Objective The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis,
irrespective of aetiology, remains controversial. This study aimed to clarify the …

The definition of acute-on-chronic liver failure (ACLF) remains contested. In Europe and
North America, the term is generally applied according to the European Association for the …