Develo** an anticancer platinum (II) compound based on the uniqueness of human serum albumin
Z Zhang, J Zhang, T Yang, S Li, G Xu… - Journal of Medicinal …, 2023 - ACS Publications
To develop the next-generation Pt drug with remarkable activity and low toxicity to maximally
inhibit tumor growth, we optimized a Pt (II) thiosemicarbazone compound (C4) with …
inhibit tumor growth, we optimized a Pt (II) thiosemicarbazone compound (C4) with …
Michael addition-driven synthesis of cytotoxic palladium (ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity through in vitro and in …
Three Pd (II) complexes (1–3) containing tridentate chromone-based thiosemicarbazones
(SVSHL1–3) have been investigated as potential anticancer agents. The complexes of the …
(SVSHL1–3) have been investigated as potential anticancer agents. The complexes of the …
Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn (II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy
We implemented isosteric replacement of sulfur to selenium in a novel thiosemicarbazone
(PPTP4c4mT) to create a selenosemicarbazone (PPTP4c4mSe) that demonstrates …
(PPTP4c4mT) to create a selenosemicarbazone (PPTP4c4mSe) that demonstrates …
Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series
The di-2-pyridylketone thiosemicarbazones demonstrated marked anticancer efficacy,
prompting progression of DpC to clinical trials. However, DpC induced deleterious oxy …
prompting progression of DpC to clinical trials. However, DpC induced deleterious oxy …
Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp) …
Innovative N-acridine thiosemicarbazones (NATs) were designed along with their iron (III),
copper (II), and zinc (II) complexes. Lysosomal targeting was promoted by specifically …
copper (II), and zinc (II) complexes. Lysosomal targeting was promoted by specifically …
Novel mono-, bi-, tri-and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis
X Wang, M Zhu, S Li, G Xu, Z Zhang, F Yang - Journal of Inorganic …, 2024 - Elsevier
To develop the next-generation metal agents for efficiently inhibiting tumor growth, a series
of novel mononuclear, binuclear and trinuclear copper (Cu) thiophene-2-formaldehyde …
of novel mononuclear, binuclear and trinuclear copper (Cu) thiophene-2-formaldehyde …
Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy …
The di-2-pyridylthiosemicarbazone (DpT) analogs demonstrate potent and selective anti-
proliferative activity against human tumors. The current investigation reports the synthesis …
proliferative activity against human tumors. The current investigation reports the synthesis …
Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen-and prolactin-receptors in breast cancer
The estrogen receptor-α (ER-α) is a key driver of breast cancer (BC) and the ER-antagonist,
tamoxifen, is a central pillar of BC treatment. However, cross-talk between ER-α, other …
tamoxifen, is a central pillar of BC treatment. However, cross-talk between ER-α, other …
A review on zinc, cadmium, and mercury complexes with anticancer activity
ES Moghadam, Z Emamgholipour, A Foroumadi… - Inorganic Chemistry …, 2024 - Elsevier
Over the last few years, there has been a surge in interest surrounding the exploration of the
therapeutic benefits of metal-based complexes because of their great potential in treating a …
therapeutic benefits of metal-based complexes because of their great potential in treating a …
8-hydroxyquinoline-N-oxide copper (II)-and zinc (II)-phenanthroline and bipyridine coordination compounds: Design, synthesis, structures, and antitumor evaluation
LQ Du, CJ Zeng, DY Mo, QP Qin, MX Tan… - Journal of Inorganic …, 2024 - Elsevier
Fourteen novel tumor-targeting copper (II) and zinc (II) complexes,[Cu (ONQ)(QD1)(NO 3)]·
CH 3 OH (NQ3),[Cu (ONQ)(QD2)(NO 3)](NQ2),[Cu (NQ)(QD2) Cl](NQ3),[Cu (ONQ)(QD1) …
CH 3 OH (NQ3),[Cu (ONQ)(QD2)(NO 3)](NQ2),[Cu (NQ)(QD2) Cl](NQ3),[Cu (ONQ)(QD1) …