1. INTRODUCTION In the last 139 years, 1 the pyrazole nucleus has been and somehow
remains a challenge for the design of selective synthesis. With five centers featuring different …

This review provides a comprehensive survey relating to the synthesis and biological
applications of pyrazolines and related heterocycles in the last five years (2007–2011) …

BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell
development, with loss‐of‐function mutations causing X‐linked agammaglobulinemia and …

Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are
essential mediators of intracellular signaling in both normal and neoplastic T-cells and …

Thymidine phosphorylase (TP) is an enzyme that promotes tumor growth and metastasis
and therefore is an attractive druggable target. Using a reported TP inhibitor, 7 …

A series of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,
2, 3, 4-tetrahydropyrimidine-5-carboxylic acid ethyl esters (1–16) were synthesized and …

Indole and pyrazole are two important scaffolds in the field of medicinal chemistry.
Compounds bearing indole and/or pyrazole moiety have been extensively investigated for a …

A series of novel teraryl oxazolidinone compounds was designed, synthesized, and
evaluated for their antimicrobial activity and toxicities. The compounds with aromatic N …

We describe a general approach for the synthesis of allylated and benzylated pyrazoles. An
electron-withdrawing substituent, such as nitro, chloro, and ester groups, at C4 renders the …

Designing and synthesizing high-energy, low-sensitivity energetic molecules has become
an urgent challenge in the field of energetic materials. Here, the concept of chimerism was …