Sirtuins, a promising target in slowing down the ageing process
W Grabowska, E Sikora, A Bielak-Zmijewska - Biogerontology, 2017 - Springer
Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …
Effects of oxidative stress on mesenchymal stem cell biology
RA Denu, P Hematti - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …
SIRT6, a mammalian deacylase with multitasking abilities
AR Chang, CM Ferrer… - Physiological …, 2020 - journals.physiology.org
Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …
Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications
The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was
heralded as a major breakthrough of the decade in stem cell research. The ability to …
heralded as a major breakthrough of the decade in stem cell research. The ability to …
Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …
that serves as an essential cofactor and substrate for a number of critical cellular processes …
S irtuins and their roles in Brain Aging and Neurodegenerative disorders
H Jęśko, P Wencel, RP Strosznajder… - Neurochemical …, 2017 - Springer
Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …
SIRT6: novel mechanisms and links to aging and disease
SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …
Chromatin and beyond: the multitasking roles for SIRT6
S Kugel, R Mostoslavsky - Trends in biochemical sciences, 2014 - cell.com
In recent years there has been a large expansion in our understanding of SIRT6 biology
including its structure, regulation, biochemical activity, and biological roles. SIRT6 functions …
including its structure, regulation, biochemical activity, and biological roles. SIRT6 functions …
[HTML][HTML] Sirtuin regulation in aging and injury
N Poulose, R Raju - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …
NAD and the aging process: Role in life, death and everything in between
CCS Chini, MG Tarragó, EN Chini - Molecular and cellular endocrinology, 2017 - Elsevier
Life as we know it cannot exist without the nucleotide nicotinamide adenine dinucleotide
(NAD). From the simplest organism, such as bacteria, to the most complex multicellular …
(NAD). From the simplest organism, such as bacteria, to the most complex multicellular …