Combination strategies to maximize the benefits of cancer immunotherapy
S Zhu, T Zhang, L Zheng, H Liu, W Song, D Liu… - Journal of hematology & …, 2021 - Springer
Immunotherapies such as immune checkpoint blockade (ICB) and adoptive cell therapy
(ACT) have revolutionized cancer treatment, especially in patients whose disease was …
(ACT) have revolutionized cancer treatment, especially in patients whose disease was …
The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses
A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …
Antioxidative and anti-inflammatory properties of cannabidiol
S Atalay, I Jarocka-Karpowicz, E Skrzydlewska - Antioxidants, 2019 - mdpi.com
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …
Indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the
oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune …
oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune …
Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
Myeloid cell-derived arginase in cancer immune response
Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …
becomes a promising approach in various forms of immunotherapy. Insufficient …
Tumor-infiltrating lymphocytes and their prognostic value in cutaneous melanoma
F Maibach, H Sadozai, SM Seyed Jafari… - Frontiers in …, 2020 - frontiersin.org
Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB)
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …
Targeting the IDO1 pathway in cancer: from bench to bedside
M Liu, X Wang, L Wang, X Ma, Z Gong… - Journal of hematology & …, 2018 - Springer
Abstract Indoleamine 2, 3-dioxygenases (IDO1 and IDO2) and tryptophan 2, 3-dioxygenase
(TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into …
(TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into …
Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy
P Huang, Y Yang, W Wang, Z Li, N Gao, H Chen… - Biomaterials, 2023 - Elsevier
Insufficient immune stimulation and stubborn immune resistance are the critical factors
limiting tumor immunotherapy. Here, we report a multifunctional nanoprodrug platform with …
limiting tumor immunotherapy. Here, we report a multifunctional nanoprodrug platform with …
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy
F Galli, JV Aguilera, B Palermo, SN Markovic… - Journal of experimental …, 2020 - Springer
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …
able to evade the immune response and establish a very complex balance in which different …