Osteoblasts and osteoclasts participate in the process of bone remodelling to meet the
needs of normal growth and development or repair pathological damage. Endoplasmic …

The purpose of this study was to investigate whether toll-like receptor 4 (TLR4) is implicated
in the development of endoplasmic reticulum stress (ER stress) observed after a high-fat diet …

Saturated fatty acids, such as palmitate, are elevated in metabolically dysfunctional
conditions like type 2 diabetes mellitus. Palmitate has been shown to impair insulin …

Chaperone production is an essential step for proper folding of certain proteins.
Accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER) lumen …

Chloroethanol (2CE), a metabolite of ethylene oxide (EO), vinyl chloride (VC), and 1, 2-
dichloroethene (1, 2-DCE), has an unclear toxic mechanism, complicating effective …

B cells orchestrate pro-survival and pro-apoptotic inputs during unfolded protein response
(UPR) to translate, fold, sort, secrete and recycle immunoglobulins. In common variable …

The etiology of selective immunoglobulin A deficiency (IgAD) is not yet unraveled, but
genetics seem to play an important role. Defects in processes during B-cell differentiation …

Introdução: A Imunodeficiência Comum Variável (ICV) faz parte de um grupo de
imunodeficiências primárias na qual os pacientes apresentam defeitos na maturação e …

With the substantial socio-economic progress of recent decades, diseases resulting from
malnutrition and infection have declined in several South American (SA) countries …

The purpose of this study was to investigate whether toll-like receptor 4 (TLR4) is implicated
in the development of endoplasmic reticulum stress (ER stress) observed after a high-fat diet …