Mutexa: a computational ecosystem for intelligent protein engineering

ZJ Yang, Q Shao, Y Jiang, C Jurich, X Ran… - Journal of Chemical …, 2023 - ACS Publications
Protein engineering holds immense promise in sha** the future of biomedicine and
biotechnology. This Review focuses on our ongoing development of Mutexa, a …

The role of the glycome in symbiotic host-microbe interactions

R Aminov, L Aminova - Glycobiology, 2023 - academic.oup.com
Glycosylation plays a crucial role in many aspects of cell biology, including cellular and
organismal integrity, structure-and-function of many glycosylated molecules in the cell …

Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBRUB10712) of Streptococcus gordonii

C Di Carluccio, L Cerofolini, M Moreira… - ACS Central …, 2024 - ACS Publications
Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the
human oral cavity, but can also cause local or systemic diseases. Serine-rich repeat (SRR) …

[HTML][HTML] Molecular basis of bacterial lectin recognition of eukaryotic glycans: The case of Mycoplasma pneumoniae and Mycoplasma genitalium cytoadhesins

A Marseglia, MC Forgione, M Marcos-Silva… - International Journal of …, 2024 - Elsevier
Mycoplasma pneumoniae and Mycoplasma genitalium are two emerging bacterial
pathogens that colonize the human respiratory and urogenital epithelia, respectively. Both …

Monitoring Salivary Sialic Acid and Sialidase Activity to Assess Oral Health Status: Results of a Single Site Double-Blind Study

PK Sreenivasan, B Nandlal, G Aruna… - Applied Sciences, 2023 - mdpi.com
Featured Application Sialic acid is a critical membrane constituent required to maintain
mucosal integrity. This investigation describes the biochemical quantitation of salivary sialic …

Defining mechanisms of binding utilized by the infective endocarditis pathogen Streptococcus mitis

A Narayana - 2024 - kb.osu.edu
Streptococcus mitis is an oral commensal and a common cause of subacute infective
endocarditis (IE), a bacterial infection exhibiting an upward trend in mortality and …

Expression and Biophysical Characterization of Therapeutically-Relevant Proteins: Insights into Siglecs and Beyond

GR Gheorghita - 2024 - flore.unifi.it
This research successfully demonstrated the expression, structural characterization, and
functional analysis of multiple immunomodulatory and therapeutic proteins. These findings …

[PDF][PDF] Structural and functional investigations of fibrillar adhesins

RWL Barringer, RWL Barringer - Chemistry, 2018 - research-information.bris.ac.uk
Bacteria utilise proteins termed “adhesins” to anchor themselves to target surfaces, with
bacteria from the oral cavity being perhaps the most well-studied in terms of host adherence …

[CITATION][C] Structure and functions of the adhesion complex and P116 potein of Mycoplasma pneumoniae and Mycoplasma genitalium

M Marcos Silva - Universitat Autònoma de Barcelona