The epidermal growth factor receptor (EGFR) is activated by many ligands and belongs to a
family of tyrosine kinase receptors, including ErbB2, ErbB3, and ErbB4. These receptors are …

In recent years, there has been a great deal of interest in the development of regenerative
approaches to produce hyaline cartilage ex vivo that can be utilized for the repair or …

The multilineage differentiation potential of adult tissue-derived mesenchymal progenitor
cells (MPCs), such as those from bone marrow and trabecular bone, makes them a useful …

Nitric oxide regulates cartilage destruction by causing dedifferentiation and apoptosis of
chondrocytes. We investigated the role of the mitogen-activated protein kinase subtypes …

Connective tissue growth factor/hypertrophic chondrocyte specific gene product 24
(CTGF/Hcs24) promotes proliferation and differentiation of chondrocytes in culture. We …

Cartilage development is initiated by the differentiation of mesenchymal cells into
chondrocytes. Differentiated chondrocytes in articular cartilage undergo dedifferentiation …

The majority of the vertebrate skeleton develops through the process of endochondral
ossification and involves successive steps of chondrogenesis, chondrocyte proliferation, and …

Chondrogenesis is a multistep process culminating in the establishment of a precisely
patterned template for bone formation. Previously, we identified a loss in retinoid receptor …

Articular cartilage provides mechanical support for joints and is responsible for smooth and
pain free joint movement. It it the primary tissue affected in joint diseases such as …

The differentiated phenotype of chondrocyte is rapidly lost during in vitro culture by a
process designated" dedifferentiation." In this study, we investigate the roles of protein …