Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy

M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Smart reprograming of plants against salinity stress using modern biotechnological tools

A Raza, J Tabassum, AZ Fakhar, R Sharif… - Critical reviews in …, 2023 - Taylor & Francis
Climate change gives rise to numerous environmental stresses, including soil salinity.
Salinity/salt stress is the second biggest abiotic factor affecting agricultural productivity …

Boosting plant genome editing with a versatile CRISPR-Combo system

C Pan, G Li, AA Malzahn, Y Cheng, B Leyson… - Nature Plants, 2022 - nature.com
CRISPR-Cas9, its derived base editors and CRISPR activation systems have greatly aided
genome engineering in plants. However, these systems are mostly used separately, leaving …

Efficient and multiplex gene upregulation in plants through CRISPR-Cas-mediated knockin of enhancers

Q Yao, R Shen, Y Shao, Y Tian, P Han, X Zhang… - Molecular plant, 2024 - cell.com
Gene upregulation through genome editing is important for plant research and breeding.
Targeted insertion of short transcriptional enhancers (STEs) into gene promoters may offer a …

[HTML][HTML] CRISPR/Cas genome editing technologies for plant improvement against biotic and abiotic stresses: advances, limitations, and future perspectives

Y Wang, N Zafar, Q Ali, H Manghwar, G Wang, L Yu… - Cells, 2022 - mdpi.com
Crossbreeding, mutation breeding, and traditional transgenic breeding take much time to
improve desirable characters/traits. CRISPR/Cas-mediated genome editing (GE) is a game …

Genome-edited foods

A Tuncel, C Pan, T Sprink, R Wilhelm… - Nature Reviews …, 2023 - nature.com
Genome editing can transform agriculture and shape the future of food by improving crop
yields and animal productivity, which in turn can help to achieve food security for the …

CRISPR/Cas genome editing in tomato improvement: Advances and applications

JK Tiwari, AK Singh, TK Behera - Frontiers in Plant Science, 2023 - frontiersin.org
The narrow genetic base of tomato poses serious challenges in breeding. Hence, with the
advent of clustered regularly interspaced short palindromic repeat (CRISPR)-associated …

Boosting genome editing efficiency in human cells and plants with novel LbCas12a variants

L Zhang, G Li, Y Zhang, Y Cheng, N Roberts, SE Glenn… - Genome Biology, 2023 - Springer
Background Cas12a (formerly known as Cpf1), the class II type V CRISPR nuclease, has
been widely used for genome editing in mammalian cells and plants due to its distinct …

Epigenome editing for targeted DNA (de) methylation: a new perspective in modulating gene expression

K Seem, S Kaur, S Kumar… - Critical Reviews in …, 2024 - Taylor & Francis
Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

[HTML][HTML] Molecular mechanisms of diverse auxin responses during plant growth and development

Y Zhang, J Yu, X Xu, R Wang, Y Liu, S Huang… - International Journal of …, 2022 - mdpi.com
The plant hormone auxin acts as a signaling molecule to regulate numerous developmental
processes throughout all stages of plant growth. Understanding how auxin regulates various …