Metastasis

S Gerstberger, Q Jiang, K Ganesh - Cell, 2023 - cell.com
Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

The oligometastatic spectrum in the era of improved detection and modern systemic therapy

RR Katipally, SP Pitroda, A Juloori… - Nature Reviews …, 2022 - nature.com
Metastases remain the leading cause of cancer-related mortality. The oligometastasis
hypothesis postulates that a spectrum of metastatic spread exists and that some patients …

Stereotactic ablative radiotherapy for the comprehensive treatment of oligometastatic cancers: long-term results of the SABR-COMET phase II randomized trial

DA Palma, R Olson, S Harrow, S Gaede… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE The oligometastatic paradigm hypothesizes that patients with a limited number of
metastases may achieve long-term disease control, or even cure, if all sites of disease can …

Stereotactic radiation for the comprehensive treatment of oligometastases (SABR-COMET): extended long-term outcomes

S Harrow, DA Palma, R Olson, S Gaede… - International Journal of …, 2022 - Elsevier
Purpose Long-term randomized data assessing the effect of ablative therapies in patients
with oligometastases are lacking. The Stereotactic Ablative Radiotherapy for the …

Safety and survival rates associated with ablative stereotactic radiotherapy for patients with oligometastatic cancer: a systematic review and meta-analysis

EJ Lehrer, R Singh, M Wang, VM Chinchilli… - JAMA …, 2021 - jamanetwork.com
Importance The oligometastatic paradigm postulates that patients with a limited number of
metastases can be treated with ablative local therapy to each site of disease with curative …

Stereotactic ablative body radiotherapy in patients with oligometastatic cancers: a prospective, registry-based, single-arm, observational, evaluation study

A Chalkidou, T Macmillan, MT Grzeda… - The lancet …, 2021 - thelancet.com
Background Stereotactic ablative body radiotherapy (SABR) is increasingly being used to
treat oligometastatic cancers, but high-level evidence to provide a basis for policy making is …

Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial

R Olson, L Mathews, M Liu, D Schellenberg, B Mou… - BMC cancer, 2020 - Springer
Background A recent randomized phase II trial evaluated stereotactic ablative radiotherapy
(SABR) in a group of patients with a small burden of oligometastatic disease (mostly with 1 …

Radiotherapy and immunology

L Wang, C Lynch, SP Pitroda, A Piffkó, K Yang… - Journal of Experimental …, 2024 - rupress.org
The majority of cancer patients receive radiotherapy during the course of treatment,
delivered with curative intent for local tumor control or as part of a multimodality regimen …

Approaches to the management of metastatic adenoid cystic carcinoma

RH Lee, KC Wai, JW Chan, PK Ha, H Kang - Cancers, 2022 - mdpi.com
Simple Summary Patients with adenoid cystic carcinoma (ACC) often experience late distant
metastasis years after definitive therapy, most commonly to the lungs. Currently, there is little …

Oligometastases: emerging evidence

W Liu, H Bahig, DA Palma - Journal of Clinical Oncology, 2022 - ascopubs.org
The hypothesis that ablative therapies (such as surgery or radiation) can be used to cure
patients with a limited number of metastases was influential in changing practice. Early …