Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y **e… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

p53: 800 million years of evolution and 40 years of discovery

AJ Levine - Nature Reviews Cancer, 2020 - nature.com
The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …

Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU ** - Seminars in cancer biology, 2022 - Elsevier
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Management of Helicobacter pylori infection—the Maastricht IV/Florence consensus report

P Malfertheiner, F Megraud, CA O'Morain, J Atherton… - Gut, 2012 - gut.bmj.com
Management of Helicobacter pylori infection is evolving and in this 4th edition of the
Maastricht consensus report aspects related to the clinical role of H pylori were looked at …

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

Helicobacter pylori-induced gastric inflammation and gastric cancer

F Wang, W Meng, B Wang, L Qiao - Cancer letters, 2014 - Elsevier
Helicobacter pylori (H. pylori) infect over half of the world's population. The prevalence of H.
pylori infection and the predominant genotype of H. pylori virulence factors vary …

Overview of Helicobacter pylori Infection: Clinical Features, Treatment, and Nutritional Aspects

M Öztekin, B Yılmaz, D Ağagündüz, R Capasso - Diseases, 2021 - mdpi.com
Helicobacter pylori (H. pylori) is a 0.5–1 µm wide, 2–4 µm long, short helical, S-shaped
Gram-negative microorganism. It is mostly found in the pyloric region of the stomach and …

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

M Hatakeyama - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …

Gastric cancer—molecular and clinical dimensions

R Wadhwa, S Song, JS Lee, Y Yao, Q Wei… - Nature reviews Clinical …, 2013 - nature.com
Gastric cancer imposes a considerable health burden around the globe despite its declining
incidence. The disease is often diagnosed in advanced stages and is associated with a poor …

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

X Yong, B Tang, BS Li, R **e, CJ Hu, G Luo… - Cell communication and …, 2015 - Springer
Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric
diseases but also with several extragastric diseases. The clinical outcomes caused by H …