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Signaling pathways and therapeutic interventions in gastric cancer
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
p53: 800 million years of evolution and 40 years of discovery
AJ Levine - Nature Reviews Cancer, 2020 - nature.com
The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …
suppression through an informed, regulated and integrated set of responses to …
Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
Management of Helicobacter pylori infection—the Maastricht IV/Florence consensus report
P Malfertheiner, F Megraud, CA O'Morain, J Atherton… - Gut, 2012 - gut.bmj.com
Management of Helicobacter pylori infection is evolving and in this 4th edition of the
Maastricht consensus report aspects related to the clinical role of H pylori were looked at …
Maastricht consensus report aspects related to the clinical role of H pylori were looked at …
Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis
A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …
Helicobacter pylori-induced gastric inflammation and gastric cancer
Helicobacter pylori (H. pylori) infect over half of the world's population. The prevalence of H.
pylori infection and the predominant genotype of H. pylori virulence factors vary …
pylori infection and the predominant genotype of H. pylori virulence factors vary …
Overview of Helicobacter pylori Infection: Clinical Features, Treatment, and Nutritional Aspects
Helicobacter pylori (H. pylori) is a 0.5–1 µm wide, 2–4 µm long, short helical, S-shaped
Gram-negative microorganism. It is mostly found in the pyloric region of the stomach and …
Gram-negative microorganism. It is mostly found in the pyloric region of the stomach and …
Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer
M Hatakeyama - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …
Gastric cancer—molecular and clinical dimensions
Gastric cancer imposes a considerable health burden around the globe despite its declining
incidence. The disease is often diagnosed in advanced stages and is associated with a poor …
incidence. The disease is often diagnosed in advanced stages and is associated with a poor …
Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
X Yong, B Tang, BS Li, R **e, CJ Hu, G Luo… - Cell communication and …, 2015 - Springer
Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric
diseases but also with several extragastric diseases. The clinical outcomes caused by H …
diseases but also with several extragastric diseases. The clinical outcomes caused by H …