Radical-involved transition metal (TM) catalysis has greatly enabled new reactivities in
recent decades. Copper-catalyzed radical relay offers enormous potential in C (sp3)–H …

Metal-exchanged zeolites are a class of heterogeneous catalysts that perform important
functions ranging from selective hydrocarbon oxidation to remediation of NO x pollutants …

This Perspective presents the fundamental principles, the elementary reactions, the initial
catalytic systems, and the contemporary catalysts that have converted C–H bond …

Since our initial report in 1976, the oxygen rebound mechanism has become the consensus
mechanistic feature for an expanding variety of enzymatic C–H functionalization reactions …

Direct methods for stereoselective functionalization of sp3-hybridized carbon–hydrogen [C
(sp3)–H] bonds in complex organic molecules could facilitate much more efficient …

Metalloporphyrins are widely used throughout the biosphere, and of these heme (iron
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …

Dioxygen (O2) serves two essential functions in aerobic life. It is both a terminal electron
acceptor and a biosynthetic reagent. It is this latter role for dioxygen that will be the focus of …

The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”,
referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …

Alkanes constitute the cheapest and most abundant feedstock for organic chemicals.
However, the redistribution of CsC and CsH bonds in hydrocarbons into more sophisticated …

The introduction of oxygen into biochemical processes has brought about an evolutionary
leap in the history of life, whereby many organisms have evolved to use oxygen as part of …