[HTML][HTML] Non-canonical pathways associated to Amyloid beta and tau protein dyshomeostasis in Alzheimer's disease: A narrative review

A Maggiore, V Latina, M D'Erme, G Amadoro… - Ageing Research …, 2024 - Elsevier
Alzheimer's Disease (AD) is the most common form of dementia among elderly people. This
disease imposes a significant burden on the healthcare system, society, and economy due …

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

Q Qiu, M Yang, D Gong, H Liang… - Neural Regeneration …, 2025 - journals.lww.com
The central nervous system, information integration center of the body, is mainly composed
of neurons and glial cells. The neuron is one of the most basic and important structural and …

Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EVISF) reveals sex‐dependent changes in microglial EV proteome in response to Aβ …

MC Pait, SD Kaye, Y Su, A Kumar… - Journal of …, 2024 - Wiley Online Library
Brain‐derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD),
relaying important physiological information about their host tissues. The internal cargo of …

Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer's disease

M Ramezani, M Fernando, S Eslick, PR Asih… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. AD is a progressive
neurodegenerative disorder characterized by cognitive dysfunction, including learning and …

Involvement of brain metabolism in neurodevelopmental disorders

P Kotchetkov, N Blakeley, B Lacoste - International Review of Neurobiology, 2023 - Elsevier
Neurodevelopmental disorders (NDDs) affect a significant portion of the global population
and have a substantial social and economic impact worldwide. Most NDDs manifest in early …

Novel insights into the activating transcription factor 4 in Alzheimer's disease and associated aging-related diseases: Mechanisms and therapeutic implications

N Zhang, J Nao, S Zhang, X Dong - Frontiers in Neuroendocrinology, 2024 - Elsevier
Ageing is inherent to all human beings, most mechanistic explanations of ageing results
from the combined effects of various physiological and pathological processes. Additionally …

Somatostatin and the pathophysiology of Alzheimer's disease

VN Almeida - Ageing Research Reviews, 2024 - Elsevier
Among the central features of Alzheimer's disease (AD) progression are altered levels of the
neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST …

Screening of liquid–liquid phase separation conditions for proteins with a mixed solution kit of biomacromolecular crowding agents

WY Ge, WP Shi, XT Wang, H Liang, XD Deng… - Journal of Molecular …, 2024 - Elsevier
Protein liquid–liquid phase separation (LLPS) is a significant process in biology and
material sciences. Finding suitable conditions for protein LLPS is essential for its in-depth …

Modal Analysis of Cerebrovascular Effects for Digital Health Integration of Neurostimulation Therapies—A Review of Technology Concepts

M Stefanski, Y Arora, M Cheung, A Dutta - Brain Sciences, 2024 - mdpi.com
Transcranial electrical stimulation (tES) is increasingly recognized for its potential to mod-
ulate cerebral blood flow (CBF) and evoke cerebrovascular reactivity (CVR), which are …

Exploratory Dual PET imaging of [18F] fluorodeoxyglucose and [11C] acetoacetate in type 2 diabetic nonhuman primates

I Krizan, KKS Sai, N Damuka, SL Macauley… - Bioorganic & Medicinal …, 2024 - Elsevier
Despite recent advancements in imaging (amyloid-PET & tau-PET) and fluid (Aβ42/Aβ40 &
Aβ42/ptau) biomarkers, the current standard for in vivo assessment of AD, diagnosis and …