Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective

T Ruan, P Li, H Wang, T Li, G Jiang - Chemical Reviews, 2023 - ACS Publications
Exposure to environmental organic pollutants has triggered significant ecological impacts
and adverse health outcomes, which have been received substantial and increasing …

Artificial intelligence-based multi-omics analysis fuels cancer precision medicine

X He, X Liu, F Zuo, H Shi, J **g - Seminars in Cancer Biology, 2023 - Elsevier
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …

Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

Y Zhang, L Wiese, H Fang, S Alseekh, LP de Souza… - Molecular Plant, 2023 - cell.com
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …

Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking

Z Zhou, M Luo, H Zhang, Y Yin, Y Cai, ZJ Zhu - Nature Communications, 2022 - nature.com
Liquid chromatography-mass spectrometry (LC-MS) based untargeted metabolomics allows
to measure both known and unknown metabolites in the metabolome. However, unknown …

Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome

JP Menzel, RSE Young, AH Benfield, JS Scott… - Nature …, 2023 - nature.com
Fatty acid isomers are responsible for an under-reported lipidome diversity across all
kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary …

Development of a widely targeted volatilomics method for profiling volatilomes in plants

H Yuan, G Cao, X Hou, M Huang, P Du, T Tan, Y Zhang… - Molecular plant, 2022 - cell.com
Volatile organic compounds play essential roles in plant environment interactions as well as
determining the fragrance of plants. Although gas chromatography-mass spectrometry …

Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond

AS Richter, T Nägele, B Grimm, K Kaufmann… - Plant …, 2023 - cell.com
Plastids communicate their developmental and physiological status to the nucleus via
retrograde signaling, allowing nuclear gene expression to be adjusted appropriately …

Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine

J Ren, L Yang, S Qiu, AH Zhang, XJ Wang - Trends in Endocrinology & …, 2023 - cell.com
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various
diseases. However, complexities present in HM due to the unclear bioactive compounds …