Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective
Exposure to environmental organic pollutants has triggered significant ecological impacts
and adverse health outcomes, which have been received substantial and increasing …
and adverse health outcomes, which have been received substantial and increasing …
Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …
emerging that have enabled researchers to access multi-layer information from the genome …
Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives
S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …
specific metabolites with widely varying structures that help them adapt to variable survival …
Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …
treatment against several types of solid cancers. The supply of paclitaxel from natural …
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Liquid chromatography-mass spectrometry (LC-MS) based untargeted metabolomics allows
to measure both known and unknown metabolites in the metabolome. However, unknown …
to measure both known and unknown metabolites in the metabolome. However, unknown …
Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome
Fatty acid isomers are responsible for an under-reported lipidome diversity across all
kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary …
kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary …
Development of a widely targeted volatilomics method for profiling volatilomes in plants
H Yuan, G Cao, X Hou, M Huang, P Du, T Tan, Y Zhang… - Molecular plant, 2022 - cell.com
Volatile organic compounds play essential roles in plant environment interactions as well as
determining the fragrance of plants. Although gas chromatography-mass spectrometry …
determining the fragrance of plants. Although gas chromatography-mass spectrometry …
Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond
Plastids communicate their developmental and physiological status to the nucleus via
retrograde signaling, allowing nuclear gene expression to be adjusted appropriately …
retrograde signaling, allowing nuclear gene expression to be adjusted appropriately …
Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine
J Ren, L Yang, S Qiu, AH Zhang, XJ Wang - Trends in Endocrinology & …, 2023 - cell.com
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various
diseases. However, complexities present in HM due to the unclear bioactive compounds …
diseases. However, complexities present in HM due to the unclear bioactive compounds …