Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …

Context Trans women (male sex assigned at birth, female gender identity) mostly use
antiandrogens combined with estrogens and can subsequently undergo vaginoplasty …

Prostate cancer (PCa) is the most common cancer in men in developed countries.
Epidemiological studies have associated high blood-cholesterol levels with an increased …

Prostate cancer is the most common cancer and the second leading cause of death from
cancer in males in most Western countries. Prostate cancer has an exquisite sensitivity to …

Abstract When the National Institutes of Health Mouse Models of Human Cancer Consortium
initiated the Prostate Steering Committee 15 years ago, there were no genetically …

The role of the androgen receptor (AR) signaling axis in the progression of prostate cancer
is a cornerstone to our understanding of the molecular mechanisms causing castration …

Background There is evidence from epidemiological and in vitro studies that the biological
effects of testosterone (T) on cell cycle and survival are modulated by 1, 25-dihydroxyvitamin …

The major challenge in the fight against cancer is to design new drugs that will be more
selective for cancer cells, with fewer side effects. Synthetic steroids such as cyproterone …

Cancer stem cells have been defined as cells within a tumor that possesses the capacity to
self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor …