Recent developments in two-dimensional liquid chromatography: fundamental improvements for practical applications

BWJ Pirok, DR Stoll, PJ Schoenmakers - Analytical Chemistry, 2018 - ACS Publications
Liquid chromatography (LC) is an incredibly successful analytical separation tool. Its
versatility is unprecedented because of the many different separation modes …

Recent advances on protein separation and purification methods

S Liu, Z Li, B Yu, S Wang, Y Shen, H Cong - Advances in Colloid and …, 2020 - Elsevier
Protein, as the material basis of vita, is the crucial undertaker of life activities, which
constitutes the framework and main substance of human tissues and organs, and takes part …

[HTML][HTML] Recent trends in two-dimensional liquid chromatography

RS van den Hurk, M Pursch, DR Stoll… - TrAC Trends in Analytical …, 2023 - Elsevier
Multi-dimensional liquid chromatography (MD-LC) continues to gain in popularity for
applications where conventional one-dimensional liquid chromatography is insufficient to …

Current developments in LC-MS for pharmaceutical analysis

M Beccaria, D Cabooter - Analyst, 2020 - pubs.rsc.org
Liquid chromatography (LC) based techniques in combination with mass spectrometry (MS)
detection have had a large impact on the development of new pharmaceuticals in the past …

[HTML][HTML] Novel technologies for metabolomics: More for less

P Miggiels, B Wouters, GJP van Westen… - TrAC Trends in …, 2019 - Elsevier
The human metabolome provides a direct physiological read-out of an individual's actual
health state and includes biomarkers that may predict disease or response to a treatment …

Recent applications of retention modelling in liquid chromatography

MJ den Uijl, PJ Schoenmakers… - Journal of …, 2021 - Wiley Online Library
Recent applications of retention modelling in liquid chromatography (2015–2020) are
comprehensively reviewed. The fundamentals of the field, which date back much longer, are …

Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches

J Camperi, A Goyon, D Guillarme, K Zhang, C Stella - Analyst, 2021 - pubs.rsc.org
Accelerated development of new therapeutics in an increasingly competitive landscape
requires the use of high throughput analytical platforms. In addition, the complexity of novel …

Recent advances in chromatography for pharmaceutical analysis

V D'Atri, S Fekete, A Clarke, JL Veuthey… - Analytical …, 2018 - ACS Publications
The pharmaceutical industry is one of the most regulated industries worldwide, since the
drug products have to be safe and effective. The levels of impurities and degradation …

Perspective on the future approaches to predict retention in liquid chromatography

F Gritti - Analytical Chemistry, 2021 - ACS Publications
The demand for rapid column screening, computer-assisted method development and
method transfer, and unambiguous compound identification by LC/MS analyses has pushed …

Comprehensive two-dimensional liquid chromatography

L Mondello, P Dugo, P Donato, M Herrero… - Nature Reviews …, 2023 - nature.com
Despite progress in hardware and column technology, the complexity and heterogeneity of
many samples still pose a challenge for state-of-the-art 1D liquid chromatography (LC). As …