Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

The intestinal epithelium represents the most regenerative tissue in the human body, located
in proximity to the dense and functionally diverse microbial milieu of the microbiome …

The implication of the heterogeneous spectrum of pro-and anti-inflammatory macrophages
(Macs) has been an important area of investigation over the last decade. The polarization of …

Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

Summary Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine,
is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Urea cycle impairment and its relationship to obesity and inflammation remained elusive,
partly due to the dramatic clinical presentation of classical urea cycle defects. We generated …

Macrophage metabolic plasticity enables repurposing of electron transport from energy
generation to inflammation and host defense. Altered respiratory complex II function has …

Macrophage immunotherapy represents an emerging therapeutic approach aimed at
modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have …

Extending the durability of response is the current focus in cancer immunotherapy with
immune checkpoint inhibitors (ICIs). However, factors like non-immunogenic tumor …