Therapeutically harnessing extracellular vesicles
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …
from the study of fundamental biology to a subject of significant clinical relevance. The …
PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Tumor targeting via EPR: Strategies to enhance patient responses
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions
The application of biocompatible nanocarriers in medicine has provided several benefits
over conventional treatment methods. However, achieving high treatment efficacy and deep …
over conventional treatment methods. However, achieving high treatment efficacy and deep …
[HTML][HTML] Recent preclinical and clinical progress in liposomal doxorubicin
Doxorubicin (DOX) is a potent anti-cancer agent that has garnered great interest in research
due to its high efficacy despite dose-limiting toxicities. Several strategies have been …
due to its high efficacy despite dose-limiting toxicities. Several strategies have been …
Transport of drugs from blood vessels to tumour tissue
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
Nanoparticles in the clinic
Nanoparticle/microparticle‐based drug delivery systems for systemic (ie, intravenous)
applications have significant advantages over their nonformulated and free drug …
applications have significant advantages over their nonformulated and free drug …
[HTML][HTML] Towards principled design of cancer nanomedicine to accelerate clinical translation
Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …
has recently shown promising results. However, although these advances have been …
[HTML][HTML] Hyperthermia and smart drug delivery systems for solid tumor therapy
Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …