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Biomarkers in psychiatry: concept, definition, types and relevance to the clinical reality
MS García-Gutiérrez, F Navarrete, F Sala… - Frontiers in …, 2020 - frontiersin.org
During the last years, an extraordinary effort has been made to identify biomarkers as
potential tools for improving prevention, diagnosis, drug response and drug development in …
potential tools for improving prevention, diagnosis, drug response and drug development in …
Statistical and integrative system-level analysis of DNA methylation data
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
Cross-tissue correlations of genome-wide DNA methylation in Japanese live human brain and blood, saliva, and buccal epithelial tissues
S Nishitani, M Isozaki, A Yao, Y Higashino… - Translational …, 2023 - nature.com
Neuroepigenetics considers genetic sequences and the interplay with environmental
influences to elucidate vulnerability risk for various neurological and psychiatric disorders …
influences to elucidate vulnerability risk for various neurological and psychiatric disorders …
Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology
High costs and technical limitations of cell sorting and single-cell techniques currently
restrict the collection of large-scale, cell-type-specific DNA methylation data. This, in turn …
restrict the collection of large-scale, cell-type-specific DNA methylation data. This, in turn …
Linking epigenetics and biological conservation: Towards a conservation epigenetics perspective
Biodiversity conservation is a global issue where the challenge is to integrate all levels of
biodiversity to ensure the long‐term evolutionary potential and resilience of biological …
biodiversity to ensure the long‐term evolutionary potential and resilience of biological …
Host methylation predicts SARS-CoV-2 infection and clinical outcome
IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …
Addressing the challenge of biomedical data inequality: an artificial intelligence perspective
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …
healthcare and confer the predictive power essential to precision medicine. However, the …
Methylation risk scores are associated with a collection of phenotypes within electronic health record systems
Inference of clinical phenotypes is a fundamental task in precision medicine, and has
therefore been heavily investigated in recent years in the context of electronic health records …
therefore been heavily investigated in recent years in the context of electronic health records …