The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic
classes, has led to a gradual increase in the resistance of bacterial pathogens to these …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-
resistant bacteria. Pumps may be specific for one substrate or may transport a range of …

Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

Serratia species, in particular Serratia marcescens, are significant human pathogens. S.
marcescens has a long and interesting taxonomic, medical experimentation, military …

Antibiotic resistance of bacterial pathogens is a fast emerging global crisis and an
understanding of the underlying resistance mechanisms is paramount for design and …

Serratia marcescens is a ubiquitous bacterium from order Enterobacterales displaying a
high genetic plasticity that allows it to adapt and persist in multiple niches including soil …

Serratia marcescens is an important nosocomial pathogen that can cause an array of
infections, most notably of the urinary tract and bloodstream. Naturally, it is found in many …