Advances in the immunology and genetics of leprosy

Z Mi, H Liu, F Zhang - Frontiers in immunology, 2020 - frontiersin.org
Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Innate immune responses in leprosy

RO Pinheiro, V Schmitz, BJA Silva, AA Dias… - Frontiers in …, 2018 - frontiersin.org
Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

R Kapur, M Kim, R Aslam, MJ McVey… - Blood, The Journal …, 2017 - ashpublications.org
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related
fatalities and is characterized by acute respiratory distress following blood transfusion …

The Long Noncoding RNA MALAT1 Induces Tolerogenic Dendritic Cells and Regulatory T Cells via miR155/Dendritic Cell-Specific Intercellular Adhesion Molecule-3 …

J Wu, H Zhang, Y Zheng, X **, M Liu, S Li… - Frontiers in …, 2018 - frontiersin.org
By sha** T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the
induction of immune tolerance after transplantation. However, the role of long noncoding …

What makes an allergen?

S Scheurer, M Toda, S Vieths - Clinical & Experimental Allergy, 2015 - Wiley Online Library
Allergic diseases are an immune disorder reacting to certain type of allergen (s).
Remarkably only a small number of proteins of the plant and animal proteome act as …

Leprosy as a complex infection: breakdown of the Th1 and Th2 immune paradigm in the immunopathogenesis of the disease

JR De Sousa, MN Sotto… - Frontiers in …, 2017 - frontiersin.org
Leprosy is a chronic infectious disease whose evolution involves complex immune
mechanisms of the host that influence the clinical presentation of the disease. For many …

Interleukin-10 Producing Regulatory B Cells Transformed CD4+CD25 Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy

M Tarique, H Naz, SV Kurra, C Saini, RA Naqvi… - Frontiers in …, 2018 - frontiersin.org
Regulatory B cells (Bregs) are known to exhibit their regulatory functions through interleukin-
10 (IL-10) cytokine which suppress inflammation. There are only a few studies explaining …

An update on leprosy immunopathogenesis: systematic review

MJA Silva, CS Silva, TP Brasil, AK Alves… - Frontiers in …, 2024 - frontiersin.org
Introduction Leprosy is a chronic infectious condition and the main cause of neuropathy that
occurs brought on by M. leprae. It is known that the biological characteristics of the human …

Mycobacterium tuberculosis mannose-capped lipoarabinomannan induces IL-10-producing B cells and hinders CD4+ Th1 immunity

C Yuan, ZL Qu, XL Tang, Q Liu, W Luo, C Huang… - Iscience, 2019 - cell.com
The importance of Th1/interferon (IFN)-γ-mediated responses in mycobacterial infection has
been well established. However, little is known about B cell-mediated immunity during …

IL-12 and IL-23 modulate plasticity of FoxP3+ regulatory T cells in human Leprosy

M Tarique, C Saini, RA Naqvi, N Khanna, A Sharma… - Molecular …, 2017 - Elsevier
Leprosy is a bacterial disease caused by M. leprae. Its clinical spectrum reflects the host's
immune response to the M. leprae and provide an ideal model to investigate the host …