ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

CA Devaux, JM Rolain, D Raoult - Journal of Microbiology, Immunology …, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in
Chinese people in December 2019 and has currently spread worldwide causing the COVID …

How many human proteoforms are there?

R Aebersold, JN Agar, IJ Amster, MS Baker… - Nature chemical …, 2018 - nature.com
Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition …

Classical renin-angiotensin system in kidney physiology

MA Sparks, SD Crowley, SB Gurley… - Comprehensive …, 2014 - pmc.ncbi.nlm.nih.gov
The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Angiotensin-converting enzyme in innate and adaptive immunity

KE Bernstein, Z Khan, JF Giani, DY Cao… - Nature Reviews …, 2018 - nature.com
Abstract Angiotensin-converting enzyme (ACE)—a zinc-dependent dicarboxypeptidase with
two catalytic domains—plays a major part in blood pressure regulation by converting …

Physiology of local renin-angiotensin systems

M Paul, A Poyan Mehr, R Kreutz - Physiological reviews, 2006 - journals.physiology.org
Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

SH Barage, KD Sonawane - Neuropeptides, 2015 - Elsevier
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various
therapeutic approaches are being used to improve the cholinergic neurotransmission, but …

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

S Valitutti, S Müller, M Cella, E Padovan… - Nature, 1995 - nature.com
T LYMPHOCYTES can recognize and be activated by a very small number of complexes of
peptide with major histocompatibility complex (MHC) molecules displayed on the surface of …

Angiotensin I–converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects

GH Li, GW Le, YH Shi, S Shrestha - Nutrition research, 2004 - Elsevier
Angiotensin I–converting enzyme (ACE) catalyzes the conversion of angiotensin I to
vasoconstrictor angiotensin II, and also inactivates the antihypertensive vasodilator …

ACE Polymorphisms

FA Sayed-Tabatabaei, BA Oostra, A Isaacs… - Circulation …, 2006 - ahajournals.org
Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems,
one leading to the production of angiotensin II and the other to the degradation of …

An analysis of vertebrate mRNA sequences: intimations of translational control.

M Kozak - The Journal of cell biology, 1991 - rupress.org
Five structural features in mRNAs have been found to contribute to the fidelity and efficiency
of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these …