Circadian rhythms of the hypothalamus: from function to physiology

R Van Drunen, K Eckel-Mahan - Clocks & sleep, 2021 - mdpi.com
The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

The ventral tegmental area and nucleus accumbens as circadian oscillators: implications for drug abuse and substance use disorders

DD Becker-Krail, WH Walker, RJ Nelson - Frontiers in Physiology, 2022 - frontiersin.org
Circadian rhythms convergently evolved to allow for optimal synchronization of individuals'
physiological and behavioral processes with the Earth's 24-h periodic cycling of …

Astrocyte molecular clock function in the nucleus accumbens is important for reward-related behavior

DD Becker-Krail, KD Ketchesin, JN Burns, W Zong… - Biological …, 2022 - Elsevier
Background Substance use disorders are associated with disruptions in circadian rhythms.
Both human and animal work have shown the integral role for circadian clocks in the …

Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

S Puig, X Xue, R Salisbury, MA Shelton, SM Kim… - Molecular …, 2023 - nature.com
Opioid craving and relapse vulnerability is associated with severe and persistent sleep and
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …

[HTML][HTML] The missing hallmark of health: psychosocial adaptation

C López-Otín, G Kroemer - Cell Stress, 2024 - ncbi.nlm.nih.gov
The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …

Cell-specific regulation of the circadian clock by BMAL1 in the paraventricular nucleus: Implications for regulation of systemic biological rhythms

R Van Drunen, Y Dai, H Wei, B Fekry, S Noori… - Cell reports, 2024 - cell.com
Circadian rhythms are internal biological rhythms driving temporal tissue-specific, metabolic
programs. Loss of the circadian transcription factor BMAL1 in the paraventricular nucleus …

Two players in the field: hierarchical model of interaction between the dopamine and acetylcholine signaling systems in the striatum

J Myslivecek - Biomedicines, 2021 - mdpi.com
Tight interactions exist between dopamine and acetylcholine signaling in the striatum.
Dopaminergic neurons express muscarinic and nicotinic receptors, and cholinergic …

The circadian neurobiology of reward

I Olejniczak, K Begemann, I Wilhelm… - Acta …, 2023 - Wiley Online Library
Circadian clocks are important regulators of physiology and behavior. In the brain, circadian
clocks have been described in many centers of the central reward system. They affect …

Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens

LM DePoy, KA Petersen, W Zong, KD Ketchesin… - Molecular …, 2024 - nature.com
Circadian rhythms are critical for human health and are highly conserved across species.
Disruptions in these rhythms contribute to many diseases, including psychiatric disorders …

[HTML][HTML] Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

P Tian, Y Hou, Z Wang, J Jiang, X Qian, Z Qu… - Food Science and …, 2024 - Elsevier
Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut
microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In …