Gigantic business: titin properties and function through thick and thin
The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …
The sarcomeric cytoskeleton: from molecules to motion
M Gautel, K D**ović-Carugo - Journal of Experimental …, 2016 - journals.biologists.com
Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …
unidirectional development of force and motion during heart and skeletal muscle …
Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
The physiology and pathophysiology of T-tubules in the heart
In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
[HTML][HTML] The physiological role of cardiac cytoskeleton and its alterations in heart failure
V Sequeira, LLAM Nijenkamp, JA Regan… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …
generation of force and movement central to the work generated by the heart. During each …
Emerging mechanisms of T-tubule remodelling in heart failure
Cardiac excitation–contraction coupling occurs primarily at the sites of transverse (T)-
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …
Calcium signaling in cardiomyocyte function
G Gilbert, K Demydenko, E Dries… - Cold Spring …, 2020 - cshperspectives.cshlp.org
Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …
Structural and signaling proteins in the Z-disk and their role in cardiomyopathies
The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …
Targeting cardiomyocyte Ca2 homeostasis in heart failure
Improved treatments for heart failure patients will require the development of novel
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Aims Invaginations of the cellular membrane called t-tubules are essential for maintaining
efficient excitation–contraction coupling in ventricular cardiomyocytes. Disruption of t-tubule …
efficient excitation–contraction coupling in ventricular cardiomyocytes. Disruption of t-tubule …