Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

The role of the microbiome in NAFLD and NASH

AA Kolodziejczyk, D Zheng, O Shibolet… - EMBO molecular …, 2019 - embopress.org
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of cardiometabolic
syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly …

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

L Hoyles, JM Fernández-Real, M Federici, M Serino… - Nature medicine, 2018 - nature.com
Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is
a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal …

Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease

S Lim, JW Kim, G Targher - Trends in Endocrinology & Metabolism, 2021 - cell.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition
characterized by hepatic fat accumulation combined with underlying metabolic …

FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases

EJ Tillman, T Rolph - Frontiers in endocrinology, 2020 - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Gut microbiota metabolites in NAFLD pathogenesis and therapeutic implications

J Chen, L Vitetta - International journal of molecular sciences, 2020 - mdpi.com
Gut microbiota dysregulation plays a key role in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through its metabolites. Therefore, the restoration of the gut microbiota and …

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related …

D Porras, E Nistal, S Martínez-Flórez… - Free Radical Biology …, 2017 - Elsevier
Gut microbiota is involved in obesity, metabolic syndrome and the progression of
nonalcoholic fatty liver disease (NAFLD). It has been recently suggested that the flavonoid …

Current concepts, opportunities, and challenges of gut microbiome-based personalized medicine in nonalcoholic fatty liver disease

SR Sharpton, B Schnabl, R Knight, R Loomba - Cell metabolism, 2021 - cell.com
Nonalcoholic fatty liver disease (NALFD) is now a leading cause of chronic liver disease
worldwide, in part, as a consequence of rapidly rising levels of obesity and metabolic …

Alcohol, inflammation, and microbiota in alcoholic liver disease

M Dukić, T Radonjić, I Jovanović, M Zdravković… - International journal of …, 2023 - mdpi.com
Alcoholic liver disease (ALD) is a consequence of excessive alcohol use. According to many
studies, alcohol represents a significant socioeconomic and health risk factor in today's …