Micro-CT of rodents: state-of-the-art and future perspectives

DP Clark, CT Badea - Physica medica, 2014 - Elsevier
Micron-scale computed tomography (micro-CT) is an essential tool for phenoty** and for
elucidating diseases and their therapies. This work is focused on preclinical micro-CT …

In vivo small animal micro-CT using nanoparticle contrast agents

JR Ashton, JL West, CT Badea - Frontiers in pharmacology, 2015 - frontiersin.org
Computed tomography (CT) is one of the most valuable modalities for in vivo imaging
because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily …

Targeted nanotechnology for cancer imaging

R Toy, L Bauer, C Hoimes, KB Ghaghada… - Advanced drug delivery …, 2014 - Elsevier
Targeted nanoparticle imaging agents provide many benefits and new opportunities to
facilitate accurate diagnosis of cancer and significantly impact patient outcome. Due to the …

Evaluation of X‐ray tomography contrast agents: A review of production, protocols, and biological applications

MM Koç, N Aslan, AP Kao… - Microscopy research and …, 2019 - Wiley Online Library
X‐ray computed tomography is a strong tool that finds many applications both in medical
applications and in the investigation of biological and nonbiological samples. In the clinics …

In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT

DP Clark, K Ghaghada, EJ Moding… - Physics in Medicine …, 2013 - iopscience.iop.org
Tumor blood volume and vascular permeability are well established indicators of tumor
angiogenesis and important predictors in cancer diagnosis, planning and treatment. In this …

Dual-energy CT imaging of tumor liposome delivery after gold nanoparticle-augmented radiation therapy

JR Ashton, KD Castle, Y Qi, DG Kirsch, JL West… - …, 2018 - pmc.ncbi.nlm.nih.gov
Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and
computed tomography (CT) imaging. AuNPs absorb x-rays and subsequently release low …

A neural network-based method for spectral distortion correction in photon counting x-ray CT

M Touch, DP Clark, W Barber… - Physics in Medicine & …, 2016 - iopscience.iop.org
Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for
measuring material composition based on energy dependent x-ray attenuation. Spectral CT …

Establishing the impact of vascular damage on tumor response to high-dose radiation therapy

KD Castle, DG Kirsch - Cancer research, 2019 - aacrjournals.org
Approximately half of all patients with cancer receive radiotherapy, which is conventionally
delivered in relatively small doses (1.8–2 Gy) per daily fraction over one to two months …

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

MB Cooley, D Wegierak… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Nanomedicine in oncology has not had the success in clinical impact that was anticipated in
the early stages of the field's development. Ideally, nanomedicines selectively accumulate in …

Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study

JR Ashton, DP Clark, EJ Moding, K Ghaghada… - PloS one, 2014 - journals.plos.org
Purpose To provide additional functional information for tumor characterization, we
investigated the use of dual-energy computed tomography for imaging murine lung tumors …