Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …

Metastatic disease is responsible for the majority of cancer-related deaths. We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …

Since the first half of the twentieth century, evolutionary theory has been dominated by the
idea that mutations occur randomly with respect to their consequences. Here we test this …

The unprecedented rate of extinction calls for efficient use of genetics to help conserve
biodiversity. Several recent genomic and simulation-based studies have argued that the …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

Understanding the factors that cause endangered populations to either grow or decline is
crucial for preserving biodiversity. Conservation efforts often address extrinsic threats, such …

Hybrid potato breeding will transform the crop from a clonally propagated tetraploid to a
seed-reproducing diploid. Historical accumulation of deleterious mutations in potato …

Increasing habitat fragmentation leads to wild populations becoming small, isolated, and
threatened by inbreeding depression. However, small populations may be able to purge …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …