Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

Several clinical studies on major depressive disorder (MDD) have shown that blood brain-
derived neurotrophic factor (BDNF)–a factor used to index neuroplasticity–is associated with …

Selective serotonin reuptake inhibitors (SSRIs) represent the most common treatment for
major depression. However, their efficacy is variable and incomplete. In order to elucidate …

The immediate early gene Arc is emerging as a versatile, finely tuned system capable of
coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing …

Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family of structurally
related proteins that promote neuronal differentiation and survival during development [1, 2] …

Among neurobiological mechanisms underlying antidepressant properties of ketamine,
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …

Binge drinking during adolescence is a risk factor for neuropsychiatric disorders that can
develop later in life. Histone acetylation is an important epigenetic mechanism that …

Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive
impairment. FXS patient exhibit a high comorbidity rate with autism spectrum disorders …

Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support
neuronal survival during development and promote connectivity and plasticity in the adult …

Leptin is an adipocyte-derived hormone with pleiotropic functions affecting appetite and
mood. While leptin's role in the regulation of appetite has been extensively studied in …