NMDA receptor antagonists: emerging insights into molecular mechanisms and clinical applications in neurological disorders

AO Egunlusi, J Joubert - Pharmaceuticals, 2024 - mdpi.com
Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by
progressive neuronal loss, leading to cognitive, motor, and behavioral impairments …

Mitochondrial dysfunction as the major basis of brain aging

SC Bondy - Biomolecules, 2024 - mdpi.com
The changes in the properties of three biological events that occur with cerebral aging are
discussed. These adverse changes already begin to develop early in mid-life and gradually …

Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring

L Tian, Y Zhang, J Chen, X Liu, H Nie, K Li, H Liu… - Journal of Hazardous …, 2024 - Elsevier
Microplastics have emerged as a prominent global environmental contaminant, and they
have been found in both human placenta and breast milk. However, the potential effects and …

A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level

A Merolla, C Michetti, M Moschetta, F Vacca… - Nature …, 2024 - nature.com
Epilepsy affects 1% of the general population and 30% of patients are resistant to
antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of …

A twistable aggregation induced emission enhancement active multisite fluorescent sensor for targeted sensing of zinc ions, 4-nitrophenol and chloroform in diverse …

T Javid, MA Assiri, A Pervaiz, H Irshad… - Journal of Molecular …, 2024 - Elsevier
Excessive utilization of Zn 2+ and 4-nitrophenol (4-NP) in multiple fields has been becoming
a serious threat to the environment and human health from a long time. Considering this, a …

Hypoxic-ischemic encephalopathy: pathogenesis and promising therapies

M Yang, K Wang, B Liu, Y Shen, G Liu - Molecular neurobiology, 2024 - Springer
Hypoxic-ischemic encephalopathy (HIE) is a brain lesion caused by inadequate blood
supply and oxygen deprivation, often occurring in neonates. It has emerged as a grave …

[HTML][HTML] Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Z He, L **e, J Liu, X Wei, W Zhang, Z Mei - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ischemic stroke, a devastating disease associated with high mortality and disability
worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins …

Spotlight on pro-inflammatory chemokines: regulators of cellular communication in cognitive impairment

C Wang, J Wang, Z Zhu, J Hu, Y Lin - Frontiers in Immunology, 2024 - frontiersin.org
Cognitive impairment is a decline in people's ability to think, learn, and remember, and so
forth. Cognitive impairment is a global health challenge that affects the quality of life of …

Extracellular matrix structure and interaction with immune cells in adult astrocytic tumors

A Di Vito, A Donato, J Bria, F Conforti… - Cellular and Molecular …, 2024 - Springer
The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular
component of normal and pathological tissues of the embryo and adult. ECM acts as critical …

Novel inhibitory site revealed by XAP044 Mode of Action on the metabotropic glutamate 7 receptor Venus Flytrap Domain

N Cristiano, A Cabayé, I Brabet, R Glatthar… - Journal of medicinal …, 2024 - ACS Publications
Metabotropic glutamate (mGlu) receptors play a key role in modulating most synapses in the
brain. The mGlu7 receptors inhibit presynaptic neurotransmitter release and offer …