Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a …

WJ Powers, AA Rabinstein, T Ackerson, OM Adeoye… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …

Burden of stroke in Europe: thirty-year projections of incidence, prevalence, deaths, and disability-adjusted life years

HA Wafa, CDA Wolfe, E Emmett, GA Roth, CO Johnson… - Stroke, 2020 - Am Heart Assoc
Background and purpose: Prediction of stroke impact provides essential information for
healthcare planning and priority setting. We aim to estimate 30-year projections of stroke …

2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association …

WJ Powers, AA Rabinstein, T Ackerson, OM Adeoye… - stroke, 2018 - Am Heart Assoc
2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A
Guideline for Healthcare Professionals From the American Heart Association/American Stroke …

Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of …

L Liu, W Chen, H Zhou, W Duan, S Li, X Huo… - Stroke and vascular …, 2020 - svn.bmj.com
Aim Stroke is the leading cause of disability and death in China. Ischaemic stroke accounts
for about 60%–80% of all strokes. It is of considerable significance to carry out …

Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

AK Tripathi, AK Ray, SK Mishra - Beni-Suef university journal of basic and …, 2022 - Springer
Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

A randomized trial of intraarterial treatment for acute ischemic stroke

OA Berkhemer, PSS Fransen, D Beumer… - … England Journal of …, 2015 - Mass Medical Soc
Background In patients with acute ischemic stroke caused by a proximal intracranial arterial
occlusion, intraarterial treatment is highly effective for emergency revascularization …

Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke: a statement for healthcare professionals from the …

BM Demaerschalk, DO Kleindorfer, OM Adeoye… - Stroke, 2016 - Am Heart Assoc
Purpose—To critically review and evaluate the science behind individual eligibility criteria
(indication/inclusion and contraindications/exclusion criteria) for intravenous recombinant …

[HTML][HTML] Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of …

J Emberson, KR Lees, P Lyden, L Blackwell, G Albers… - The Lancet, 2014 - thelancet.com
Background Alteplase is effective for treatment of acute ischaemic stroke but debate
continues about its use after longer times since stroke onset, in older patients, and among …