Significance: The aberrant inflammation during wound healing results in pathological
scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of …

Hypertrophic scars and keloids can have significant detrimental effects on patients both
psychosocially and functionally. A careful identification of patient risk factors and a …

Scars caused by skin injuries after burns, wounds, abrasions and operations have serious
physical and psychological effects on patients. In recent years, the research of scar free …

Angiogenesis plays a key role in the wound healing process, involving the migration,
growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance …

Hypertrophic scar (HS) tends to raised above skin level with high inflammatory
microenvironment and excessive proliferation of myofibroblasts. The HS therapy remains …

Keloids are the result of aberrant tissue scarring typically occurring in injured skin, and are
caused by the overgrowth of granulation tissue or collagen type III during the healing …

Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent
studies indicate that mechanical force significantly impacts wound healing and skin …

Hypertrophic scar (HS) is a typical pathological response during skin injury, which can lead
to pain, itching, and contracture in patients and even affect their physical and mental health …

Background Hypertrophic scars (HS) affect millions of people each year and require better
treatment strategies. Bacterial extracellular vesicles (EVs) are advantaged by low cost and …

Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors
are well-known contributors to scar formation, the precise underlying mechanisms remain …