The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Methods used to evaluate pain behaviors in rodents
Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …
in humans may be difficult to perform and ethically limited. As pain cannot be directly …
Etiology and pharmacology of neuropathic pain
Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …
[HTML][HTML] Peptide therapeutics from venom: Current status and potential
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
Structural basis for the modulation of voltage-gated sodium channels by animal toxins
INTRODUCTION Almost all venoms contain toxins that modulate the activity of voltage-gated
sodium (Nav) channels in order to incapacitate prey or predators. The single-chain …
sodium (Nav) channels in order to incapacitate prey or predators. The single-chain …
Antibodies and venom peptides: new modalities for ion channels
Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …
Peripheral voltage-gated cation channels in neuropathic pain and their potential as therapeutic targets
SRA Alles, PA Smith - Frontiers in Pain Research, 2021 - frontiersin.org
The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …
neurons is imperative for the development and persistence of many forms of neuropathic …
A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1. 7
Deletion of SCN9A encoding the voltage-gated sodium channel Na V 1.7 in humans leads
to profound pain insensitivity and anosmia. Conditional deletion of Na V 1.7 in sensory …
to profound pain insensitivity and anosmia. Conditional deletion of Na V 1.7 in sensory …
Ion channels as therapeutic antibody targets
CJ Hutchings, P Colussi, TG Clark - MAbs, 2019 - Taylor & Francis
It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …
Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?
In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …