Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …

Abstract Alzheimer's disease (AD), the most common cause of dementia, leads to neuronal
damage and deterioration of cognitive functions in aging brains. There is evidence …

The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …

MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-
transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs …

MicroRNAs, the non-coding single-stranded RNA of 19–25 nucleotides are emerging as
robust players of gene regulation. Plethora of evidences support that the ability of …

Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown
pathogenesis. Given their prominent role in brain function and disease, we hypothesized …

A major clinical hurdle to translate MSC-derived extracellular vesicles (EVs) is the lack of a
method to scale-up the production of EVs with customized therapeutic properties. In this …