[HTML][HTML] Inherited cardiomyopathies: molecular genetics and clinical genetic testing in the postgenomic era
P Teekakirikul, MA Kelly, HL Rehm… - The Journal of Molecular …, 2013 - Elsevier
Inherited cardiomyopathies include hypertrophic cardiomyopathy, dilated cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …
Role of the Wnt‐Frizzled system in cardiac pathophysiology: a rapidly develo**, poorly understood area with enormous potential
Abstract The Wnt‐Frizzled (Fzd) G‐protein‐coupled receptor system, involving 19 distinct
Wnt ligands and 10 Fzd receptors, plays key roles in the development and functioning of …
Wnt ligands and 10 Fzd receptors, plays key roles in the development and functioning of …
The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy
Rationale: Mutations in the intercalated disc proteins, such as plakophilin 2 (PKP2), cause
arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac …
arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac …
Overview of high throughput sequencing technologies to elucidate molecular pathways in cardiovascular diseases
High throughput sequencing technologies have become essential in studies on genomics,
epigenomics, and transcriptomics. Although sequencing information has traditionally been …
epigenomics, and transcriptomics. Although sequencing information has traditionally been …
Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells
O Caspi, I Huber, A Gepstein, G Arbel… - Circulation …, 2013 - Am Heart Assoc
Background—Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart
muscle disorder resulting from desmosomal protein mutations. ARVC is characterized …
muscle disorder resulting from desmosomal protein mutations. ARVC is characterized …
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence
A Lluch, J Latorre, A Serena-Maione, I Espadas… - Nature …, 2023 - nature.com
Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is
known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to …
known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to …
Ventricular arrhythmias associated with long-term endurance sports: what is the evidence?
H Heidbuchel, DL Prior, A La Gerche - British journal of sports …, 2012 - bjsm.bmj.com
Athletic performance tests the limits of the human body and mind. Awe-inspiring
achievements is what makes sports so fascinating. It is well appreciated however that top …
achievements is what makes sports so fascinating. It is well appreciated however that top …
Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations
Objectives: The purpose of this study was to assess myocardial blood flow (MBF) using
positron emission tomography in patients with hypertrophic cardiomyopathy (HCM) …
positron emission tomography in patients with hypertrophic cardiomyopathy (HCM) …
Adipose tissue: friend or foe?
The perception of adipose tissue has changed considerably with the dramatic increase in
the incidence of obesity and obesity-related comorbidities over the past 3 decades. Excess …
the incidence of obesity and obesity-related comorbidities over the past 3 decades. Excess …
Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy
R Lombardi, M da Graca Cabreira-Hansen… - Circulation …, 2011 - Am Heart Assoc
Rationale: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease of
desmosome proteins characterized by fibroadipogenesis in the myocardium. We have …
desmosome proteins characterized by fibroadipogenesis in the myocardium. We have …