The anti-malarial drugs chloroquine (CQ) and primarily the less toxic hydroxychloroquine
(HCQ) are currently used to treat autoimmune diseases for their immunomodulatory and anti …

Microparticles (MPs) derived from platelets, monocytes, endothelial cells, red blood cells,
and granulocytes may be detected in low concentrations in normal plasma and at increased …

Supported lipid bilayers (SLBs) are popular models of cell membranes with potential bio-
technological applications. A qualitative understanding of the process of SLB formation after …

Annexins are a family of structurally related proteins that exhibit Ca2+-dependent binding to
phospholipids. They have been described in many organisms from mammals to molds and …

It has been widely accepted that microparticles expose phosphatidylserine which in turn
binds annexin V. It was the objective of this study to compare the antigenic characteristics …

Autoantibodies directed against a variety of nuclear, cytoplasmic and extracellular
autoantigens are a serological hallmark of systemic sclerosis. This review provides an …

Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of
plasma membrane disruptions. Before resealing, the torn membrane is submitted to …

Background The mechanisms of vascular thrombosis and pregnancy loss in the
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …

Abstract Annexin A5 (AnxA5) is a potent anticoagulant protein that crystallizes over
phospholipid bilayers (PLBs), blocking their availability for coagulation reactions …

Annexin V belongs to a family of phospholipid binding proteins, the Annexins. It binds in the
presence of Ca 2+-ions with high affinity to negatively charged phospholipids like …