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Neuroinflammation in Alzheimer disease
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies
J Zhang, Y Zhang, J Wang, Y ** diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
[HTML][HTML] Factors influencing the blood-brain barrier permeability
Y Zhao, L Gan, L Ren, Y Lin, C Ma, X Lin - Brain research, 2022 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …
blood-borne, endogenous and exogenous substances and maintains the homeostatic …
[HTML][HTML] Blood–brain barrier breakdown in Alzheimer's disease: Mechanisms and targeted strategies
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …
Physiological blood–brain transport is impaired with age by a shift in transcytosis
The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …