Macrophage polarization in leishmaniasis: broadening horizons

F Tomiotto-Pellissier, BTS Bortoleti, JP Assolini… - Frontiers in …, 2018 - frontiersin.org
Leishmaniasis is a vector-borne neglected tropical disease that affects more than 700,000
people annually. Leishmania parasites cause the disease, and different species trigger a …

[HTML][HTML] Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism

C Bogdan - Cytokine: X, 2020 - Elsevier
Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

[HTML][HTML] Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research

EK Elmahallawy, AAM Alkhaldi, AA Saleh - Biomedicine & …, 2021 - Elsevier
Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

The cytokine/chemokine response in Leishmania/HIV infection and co-infection

S Maksoud, J El Hokayem - Heliyon, 2023 - cell.com
HIV infection progressively weakens the immune system by infecting and destroying cells
involved in host defense. Viral infection symptoms are generated and aggravated as …

The pathogenicity and virulence of Leishmania-interplay of virulence factors with host defenses

AK Gupta, S Das, M Kamran, SA Ejazi, N Ali - Virulence, 2022 - Taylor & Francis
Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …

Determinants of innate immunity in visceral leishmaniasis and their implication in vaccine development

G Volpedo, T Pacheco-Fernandez… - Frontiers in …, 2021 - frontiersin.org
Leishmaniasis is endemic to the tropical and subtropical regions of the world and is
transmitted by the bite of an infected sand fly. The multifaceted interactions between …

Host–pathogen interaction in leishmaniasis: immune response and vaccination strategies

H Yasmin, A Adhikary, MN Al-Ahdal, S Roy, U Kishore - Immuno, 2022 - mdpi.com
Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …

Leishmania Spp-Host Interaction: There Is Always an Onset, but Is There an End?

F Conceição-Silva, FN Morgado - Frontiers in cellular and infection …, 2019 - frontiersin.org
For a long time Leishmaniasis had been considered as a neglected tropical disease.
Recently, it has become a priority in public health all over the world for different aspects such …

Immunometabolism of Leishmania granulomas

EC Saunders, MJ McConville - Immunology and cell biology, 2020 - Wiley Online Library
Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized
by the formation of granulomatous lesions in the skin or other tissues, such as liver and …

Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition

H Chen, S Huang, P Niu, Y Zhu, J Zhou, L Jiang… - Molecular Therapy …, 2022 - cell.com
Ovarian cancer is the most fatal tumor characterized by an abundance of tumor-associated
macrophage (TAM) infiltrations in women. Functional TAMs, which mainly present M2-like …